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Title: Integron-encoded GES-type extended-spectrum beta-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa. Author: Poirel L, Brinas L, Fortineau N, Nordmann P. Journal: Antimicrob Agents Chemother; 2005 Aug; 49(8):3593-7. PubMed ID: 16048994. Abstract: A Pseudomonas aeruginosa strain expresses an extended-spectrum beta-lactamase, GES-9, which differs from GES-1 by a Gly243Ser substitution, is inhibited by clavulanic acid and imipenem, and hydrolyzes aztreonam. The bla(GES-9) gene was located inside a class 1 integron structure containing two copies of a novel insertion sequence belonging to the IS1111 family.[Abstract] [Full Text] [Related] [New Search]