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  • Title: Integron-encoded GES-type extended-spectrum beta-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa.
    Author: Poirel L, Brinas L, Fortineau N, Nordmann P.
    Journal: Antimicrob Agents Chemother; 2005 Aug; 49(8):3593-7. PubMed ID: 16048994.
    Abstract:
    A Pseudomonas aeruginosa strain expresses an extended-spectrum beta-lactamase, GES-9, which differs from GES-1 by a Gly243Ser substitution, is inhibited by clavulanic acid and imipenem, and hydrolyzes aztreonam. The bla(GES-9) gene was located inside a class 1 integron structure containing two copies of a novel insertion sequence belonging to the IS1111 family.
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