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  • Title: LC-NMR coupling technology: recent advancements and applications in natural products analysis.
    Author: Exarchou V, Krucker M, van Beek TA, Vervoort J, Gerothanassis IP, Albert K.
    Journal: Magn Reson Chem; 2005 Sep; 43(9):681-7. PubMed ID: 16049952.
    Abstract:
    An overview of recent advances in nuclear magnetic resonance (NMR) coupled with separation technologies and their application in natural product analysis is given and discussed. The different modes of LC-NMR operation are described, as well as how technical improvements assist in establishing LC-NMR as an important tool in the analysis of plant-derived compounds. On-flow, stopped-flow and loop-storage procedures are mentioned, together with the new LC-SPE-NMR configuration. The implementation of mass spectrometry in LC-NMR is also useful on account of the molecular weight and fragmentation information that it provides, especially when new plant species are studied. Cryogenic technology and capillary LC-NMR are the other important recent developments. Since the plant kingdom is endless in producing potential drug candidates, development and optimization of LC-NMR techniques convert the study of natural products to a less-time-consuming task, speeding up identification.
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