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  • Title: Sequential Pd(II)-Pd(0) catalysis for the rapid synthesis of coumarins.
    Author: Li K, Zeng Y, Neuenswander B, Tunge JA.
    Journal: J Org Chem; 2005 Aug 05; 70(16):6515-8. PubMed ID: 16050721.
    Abstract:
    Electrophilic palladium-catalyzed cycloisomerization of brominated aryl propiolates produces brominated coumarins. The brominated coumarins can be diversified by reduction of the Pd(II) catalyst to Pd(0) followed by Suzuki, Sonogashira, Heck, or Hartwig-Buchwald coupling. Thus, a single loading of precatalyst can be used to conduct sequential reactions, allowing the synthesis of functionalized coumarins. Extension of this methodology toward the synthesis of coumarin libraries is discussed.
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