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  • Title: Retinoid receptor subtypes in sebaceous cell carcinoma of the eyelid.
    Author: Chakravarti N, Saadati HG, El-Naggar AK, Lotan R, Diba RE, Esmaeli B.
    Journal: Ophthalmic Plast Reconstr Surg; 2005 Jul; 21(4):292-7. PubMed ID: 16052143.
    Abstract:
    PURPOSE: To study retinoid receptor expression in sebaceous cell carcinoma of the eyelid. METHODS: Expression of retinoid receptors (RAR alpha, beta, and gamma and RXR alpha, beta, and gamma) in tumor specimens from 10 patients with sebaceous cell carcinoma of the eyelid and in 3 normal incidental tarsus specimens from healthy adults without cancer was studied immunohistochemically by using antiretinoid receptor antibodies. RESULTS: In all 3 specimens of normal tarsus, all 6 retinoid receptors were expressed. RARalpha expression was absent in 3 tumors and was decreased in 3 tumors compared with expression in the control tissues. RARbeta expression in carcinomas was primarily perinuclear; 6 tumors showed increased RARbeta expression compared with controls. RARgamma expression was absent in 4 tumors and was decreased in 2 tumors compared with controls. RXRalpha nuclear expression was decreased compared with controls in 5 tumors. RXRbeta expression was low in 7 tumors. RXRgamma expression was absent in 6 tumors. CONCLUSIONS: Aberrant expression of retinoid receptors in sebaceous cell carcinoma of the eyelid might play a role in the pathogenesis and progression of this carcinoma.
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