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  • Title: GC-MS analysis of acylated derivatives of the side chain and ring regioisomers of methylenedioxymethamphetamine.
    Author: Awad T, DeRuiter J, Clark CR.
    Journal: J Chromatogr Sci; 2005 Jul; 43(6):296-303. PubMed ID: 16053611.
    Abstract:
    The perfluoroacyl derivatives (pentafluoropropionylamides and heptafluorobutrylamides) of the primary and secondary regioisomeric amines, related to the controlled drug substance 3,4-methylenedioxymethamphetamine, are prepared and evaluated in GC-MS studies. These derivatives show excellent resolution on nonpolar stationary phases, such as RTX-1 and RTX-5, with elution order differences from those of the underivatized amines. The mass spectra for these derivatives are significantly individualized, and the resulting unique fragment ions allow for specific side-chain identification. The individualization is the result of fragmentation of the alkyl carbon-nitrogen bond, yielding hydrocarbon fragments and other unique ions. The heptafluoro butrylamides derivatives offer more fragment ions for molecular individualization among these regioisomeric substances.
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