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  • Title: Out of synch: Clock mutation causes obesity in mice.
    Author: Williams DL, Schwartz MW.
    Journal: Cell Metab; 2005 Jun; 1(6):355-6. PubMed ID: 16054082.
    Abstract:
    The Clock gene encodes an essential component of the "master clock" driving circadian rhythm in the hypothalamic suprachiasmatic nucleus (SCN). New evidence that Clock mutant mice are hyperphagic and obese suggests a previously unrecognized link between molecular controls of circadian rhythm and energy homeostasis.
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