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  • Title: Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine.
    Author: Lee CW, Cao H, Ichiyama K, Rana TM.
    Journal: Bioorg Med Chem Lett; 2005 Oct 01; 15(19):4243-6. PubMed ID: 16054360.
    Abstract:
    By performing RNA-targeted structure-activity relationship studies, we discovered a novel peptidomimetic containing squaryldiamide as a potential bioisostere replacement for guanidine that binds transactivation responsive RNA with high affinity.
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