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  • Title: Effects of glucocorticoids on the hypothalamic-pituitary-adrenal axis in children and adults.
    Author: Gulliver T, Eid N.
    Journal: Immunol Allergy Clin North Am; 2005 Aug; 25(3):541-55, vii. PubMed ID: 16054542.
    Abstract:
    Inhaled and intranasal corticosteroids are widely used as effective, first-line treatments for asthma and allergic rhinitis. Despite a good safety profile of these formulations, there is increasing concern about their propensity to produce systemic adverse effects. Suppression of the hypothalamic-pituitary-adrenal axis is one of the most important potential complications. This article reviews the effects of inhaled and intranasal corticosteroids on the hypothalamic-pituitary-adrenal axis function in adults and children.
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