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  • Title: Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents.
    Author: Agarwal A, Srivastava K, Puri SK, Chauhan PM.
    Journal: Bioorg Med Chem; 2005 Nov 15; 13(22):6226-32. PubMed ID: 16054819.
    Abstract:
    A series of 2,4,6-trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds showed MIC in the range of 0.25-2 microg/mL. These compounds are in vitro several fold more active than pyrimethamine.
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