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  • Title: Intrinsic firing properties of developing rat superficial dorsal horn neurons.
    Author: Baccei ML, Fitzgerald M.
    Journal: Neuroreport; 2005 Aug 22; 16(12):1325-8. PubMed ID: 16056133.
    Abstract:
    Neonatal superficial dorsal horn neurons exhibit distinct firing properties in response to nociceptive and tactile inputs, but it is not known whether the intrinsic membrane excitability of these neurons changes during the early postnatal period. We have investigated the evoked firing properties of dorsal horn cells in rat spinal cord slices at different postnatal ages (P3, P10 and P21) and found no significant differences in mean firing frequency, spike frequency adaptation, regularity of action potential discharge or rheobase current levels between age groups. These results demonstrate that the intrinsic excitability of superficial dorsal horn neurons remains stable during early postnatal development and suggest that alterations in the synaptic inputs to these cells explain the changes in response to peripheral stimulation.
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