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  • Title: Ubiquitin signalling in the NF-kappaB pathway.
    Author: Chen ZJ.
    Journal: Nat Cell Biol; 2005 Aug; 7(8):758-65. PubMed ID: 16056267.
    Abstract:
    The transcription factor NF-kappaB (nuclear factor kappa enhancer binding protein) controls many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates at least three steps in the NF-kappaB pathway: degradation of IkappaB (inhibitor of NF-kappaB), processing of NF-kappaB precursors, and activation of the IkappaB kinase (IKK). Recent studies have revealed several enzymes involved in the ubiquitination and deubiquitination of signalling proteins that mediate IKK activation through a degradation-independent mechanism.
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