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  • Title: Impairment of antigen-presenting cell function by ultraviolet radiation.
    Author: Greene MI, Sy MS, Kripke M, Benacerraf B.
    Journal: Proc Natl Acad Sci U S A; 1979 Dec; 76(12):6591-5. PubMed ID: 160568.
    Abstract:
    UV light irradiation of BALB/c mice was found to result in impairment of antigen-presenting cell function. Adherent trinitrophenyl-derivatized cells from the peritoneal exudate cell population or the spleen of UV-treated donors could not induce hapten-specific delayed hypersensitivity responses in UV-irradiated syngeneic mice, whereas adherent trinitrophenyl-derivatized cells from normal mice were able to do so. The failure to induce immunity in UV-treated mice by utilizing UV-treated adherent antigen-presenting cells was associated with the development of antigen-specific suppressor T cells. The implication of these results for UV-induced carcinogenesis is discussed.
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