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  • Title: Spontaneous fractures in a patient treated with low doses of etidronic acid (disodium etidronate).
    Author: Eyres KS, Marshall P, McCloskey E, Douglas DL, Kanis JA.
    Journal: Drug Saf; 1992; 7(2):162-5. PubMed ID: 1605902.
    Abstract:
    The recommended regimen of etidronic acid (disodium etidronate) for the treatment of Paget's disease of bone is 5mg/kg/day for a period of less than six months. There have, however, been reports of impaired mineralisation of bone and concern that the risk of fracture is increased with this dosage. We report a patient with Paget's disease in whom fractures occurred through pagetic and non-pagetic bone which appeared to be causally related to treatment with lose doses of etidronic acid. The osteomalacia resolved when etidronic acid was discontinued.
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