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  • Title: Evaluation of the microsphere-method for determination of cardiac output.
    Author: Segadal L, Svanes K.
    Journal: Scand J Clin Lab Invest; 1979 Sep; 39(5):415-21. PubMed ID: 160609.
    Abstract:
    Cardiac output was determined by means of radioactive microspheres, 15 +/- 5 microns in diameter. Blood flow in the ascending aorta was measured by an electromagnetic flowmeter. In eight cats thirty-eight simultaneous measurements were made of cardiac output and aortic flow. The observations correlated well (r = 0.89), with a mean difference of 5.2%, probably corresponding to coronary blood flow. Continuous flow recordings showed no alterations in aortic flow during the injections of microspheres; arterial blood pressure and heart rate remained unchanged even after six injections, each consisting of about 2 x 10(5) spheres per kg body weight. Tests for shunting of microspheres were performed and revealed shunt fractions in the systemic circulation of about 8%, with no significant shunting through the lungs. The microsphere method for determining cardiac output is thought to be an accurate method, suitable for small and medium sized animals.
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