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  • Title: ACTH response to LPS in the first stages of development of the fish Dicentrarchus labrax L.
    Author: Mola L, Gambarelli A, Pederzoli A, Ottaviani E.
    Journal: Gen Comp Endocrinol; 2005 Sep 01; 143(2):99-103. PubMed ID: 16061067.
    Abstract:
    ACTH and ACTH receptor-like molecules were found at the examined stages of development (2, 4, 8, 12, 18, and 24 days post-hatching) in yolk sac, pronephros tubules, interrenal tissue, thymus, liver, spleen, cardinal veins, and skin of the teleost fish Dicentrarchus labrax. ACTH and the related receptor-like molecules show a similar distribution. LPS treatment at two different stages (8 and 24 days post-hatching) provoked both a release and an induction of ACTH-like molecules, suggesting an important role of this peptide to control the modifications in body homeostasis during the first period of the sea bass' life, i.e., 30 days post-hatching, before the lymphoid cells have reached complete maturation.
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