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Title: Saving the ends for last: the role of pol mu in DNA end joining. Author: Paull TT. Journal: Mol Cell; 2005 Aug 05; 19(3):294-6. PubMed ID: 16061176. Abstract: At least three DNA polymerases participate in nonhomologous end joining in mammalian cells: pol mu, pol kappa, and TdT. A study in this issue of Molecular Cell (Nick McElhinny et al., 2005) clarifies the role of pol mu in end joining at the kappa light chain locus and also provides a biochemical explanation for the unique polymerization functions of pol mu on DNA ends.[Abstract] [Full Text] [Related] [New Search]