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  • Title: Balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus.
    Author: Jacobi AM, Diamond B.
    Journal: J Exp Med; 2005 Aug 01; 202(3):341-4. PubMed ID: 16061723.
    Abstract:
    The autoimmune disease systemic lupus erythematosus (SLE) is caused by a failure of B cell tolerance. Recent studies in mouse models of SLE have identified several distinct tolerance checkpoints that must each function appropriately to protect against disease. However, studies of B cell repertoire selection in humans are essential to understand which checkpoints are defective in human autoimmune diseases.
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