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  • Title: AgNOR counts are useful in cervical smears.
    Author: Cardillo MR.
    Journal: Diagn Cytopathol; 1992; 8(3):208-10. PubMed ID: 1606878.
    Abstract:
    Because they present marked cellular changes, the cytological appearances of epithelial repair may be confused with those of cancer. To see whether the Ag-NOR staining technique for nucleolar organizer regions would be useful to distinguish benign proliferative reactions (squamous metaplasia and repair) from cervical intra-epithelial neoplasia (CIN I, CIN II, and CIN III), we studied a series of cervical smears. The smears, previously stained with the Papanicolaou technique, were destained and restained with Ag-NOR silver. Significantly different (P less than 0.05) Ag-NOR counts were found in squamous metaplasia, epithelial repair, and various degrees of CIN. The Ag-NOR technique appears useful in the diagnosis of cervical cytology and particularly in cases with marked cellular change, which could be confused with neoplasia.
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