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  • Title: Targeting signal of the peroxisomal catalase in the methylotrophic yeast Hansenula polymorpha.
    Author: Didion T, Roggenkamp R.
    Journal: FEBS Lett; 1992 Jun 01; 303(2-3):113-6. PubMed ID: 1607006.
    Abstract:
    The methylotrophic yeast, Hansenula polymorpha, harbours a unique catalase (EC 1.11.1.6), which is essential for growth on methanol as a carbon source and is located in peroxisomes. Its corresponding gene has been cloned and the nucleotide sequence determined. The deduced amino acid sequence displayed the tripeptide serine-lysine-isoleucine at the extreme C-terminus, which is similar to sequences of other peroxisomal targeting signals. Exchange of the ultimate amino acid, isoleucine, of catalase for serine revealed a cytosolic enzyme activity and a concomitant loss of peroxisome function. We concluded that the tripeptide is essential for targeting of catalase in H. polymorpha.
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