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  • Title: Adhesive bone cement containing hydroxyapatite particle as bone compatible filler.
    Author: Ishihara K, Arai H, Nakabayashi N, Morita S, Furuya K.
    Journal: J Biomed Mater Res; 1992 Jul; 26(7):937-45. PubMed ID: 1607374.
    Abstract:
    Acrylic bone cement containing hydroxyapatite (HA) as a filler was developed using 4-methacryloyloxyethyl trimellitate anhydride (4-META) to promote adhesion both to bone and HA. The mechanical strengths of the cement did not decrease significantly with increasing HA in the cement by 4-META. However, strengths decreased with increasing HA content in the absence of 4-META. Scanning electron micrographic examination of fractured surfaces of the cement clearly showed that the HA particles adhered to the matrix resin when 4-META was added. Thus, it was important to maintain the original mechanical strengths for 4-META. The HA particles along the surface increased with increased HA content in the cement. The cement adhered to bone with a tensile bond strength was higher than 10 MPa.
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