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  • Title: Differences in regional capillary distribution and myocyte sizes in normal and hypertrophic rat hearts.
    Author: Gerdes AM, Callas G, Kasten FH.
    Journal: Am J Anat; 1979 Dec; 156(4):523-31. PubMed ID: 160753.
    Abstract:
    Data are reported which show significant regional capillary differences in left ventricular endocardium and epicardium of normal rats and of rats with hyperthyroid-induced cardiac hypertrophy. The epicardial region of control rats has 38% more capillaries than the endocardial region. Control endocardial myocytes are 62% larger in cross-sectional area than epicardial myocytes. Hypertrophic hearts exhibit regional differences in capillary density similar to those in the normal hearts, but there is an overall reduction of 12 and 17.5% in capillary density in both regions. The average cross-sectional area of myocytes increases 34.5% in the epicardium and 22.5% in the endocardium.
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