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  • Title: [Immune modulatory and therapeutic effect of BCG polysaccharides nucleic acid on perennial allergic rhinitis].
    Author: Tang S, Zhao B, Zhang G, Liu L, Zhou T.
    Journal: Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2005 Apr; 19(8):345-6. PubMed ID: 16075984.
    Abstract:
    OBJECTIVE: To observe the immune modulatory and therapeutic effect of BCG polysaccharides nucleic acid (BCG-PSN) on patients with perennial allergic rhinitis. METHOD: Sixty patients with perennial allergic rhinitis were randomly divided into two groups, 30 in the test group were treated with BCG-PSN plus ketotefen and 30 in the control group were treated with ketotefen respectively. All patients were followed up and assessed for 3 months, and the blood samples were collected before treatment and 3 months after treatment for measuring the blood IgA, IgG, IgM, IgE, CD3, CD4 and CD8. RESULT: In the test group, the total effective rate was significantly higher comparable to that in the control group. After treatment of BCG-PSN, blood CD3, CD4 and CD4/CD8 were significantly increased. IgE significantly reduced (P < 0.05). CONCLUSION: BCG polysaccharides nucleic acid can modulate the cellular immunofunction of patients with perennial allergic rhinitis and can increase the curative rate on perennial allergic rhinitis.
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