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  • Title: Successful treatment of Aspergillus prosthetic valve endocarditis with oral voriconazole.
    Author: Reis LJ, Barton TD, Pochettino A, Velazquez O, McGarvey M, Milas B, Reboli A, Schuster MG.
    Journal: Clin Infect Dis; 2005 Sep 01; 41(5):752-3. PubMed ID: 16080100.
    Abstract:
    Aspergillus endocarditis is very difficult to cure, even with aggressive surgical debridement and antifungal therapy. Patients with embolic involvement of the central nervous system have an extremely poor prognosis. We describe a patient with prosthetic valve endocarditis due to Aspergillus fumigatus who developed emboli in the brain, eye, and lower extremities. With aggressive surgical debridement of involved sites, aortic valve and root replacement, and long-term therapy with oral voriconazole, he remains without any evidence of infection 2 years later.
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