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  • Title: [Relationship between the aldosterone synthase (CYP11B2)-344C/T polymorphism and small artery compliance].
    Author: Li XL, Liang LR, Ni CH, Wang ZZ, Li AP, Liao J, Zhou JW, Cao KJ, Huang J.
    Journal: Zhonghua Xin Xue Guan Bing Za Zhi; 2005 Jul; 33(7):599-602. PubMed ID: 16080805.
    Abstract:
    OBJECTIVE: To investigate the relationship between the aldosterone synthase (CYP11B2)-344C/T polymorphism and small artery compliance (C(2)). METHODS: C(2) was measured by CVProfilor DO-2020 in 224 subjects, including 123 subjects with an abnormal C(2) and 101 normal controls. Genotypes of CYP11B2 were determined by polymerase chain reaction-based restriction fragment length polymorphism analysis. RESULTS: The frequencies of the CYP11B TT genotype and T allele in subjects with an abnormal C(2) were slightly higher than in normal controls, but the differences did not reach statistical significance (55.3% vs 41.6%, P > 0.05, 75.6% vs 66.8%, P > 0.05. However, when CT was combined with CC, the frequency of TT in subjects with an abnormal C(2) was significantly higher than in normal controls (P < 0.05). By CANOVA, TT subjects had a lower C(2) than CT and CC subjects (P < 0.05). Logistic regression analysis revealed that TT genotype was associated with abnormal C(2) (P = 0.043, OR = 1.93 95% CI 1.02-3.63). CONCLUSIONS: The CYP11B-344C/T polymorphism is associated with small artery compliance, and TT subjects are susceptible to abnormality of small arterial compliance.
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