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  • Title: Leukemia inhibitory factor signaling is implicated in embrionic development of the HPA axis.
    Author: Ware CB, Kariagina A, Zonis S, Alon D, Chesnokova V.
    Journal: FEBS Lett; 2005 Aug 15; 579(20):4465-9. PubMed ID: 16081071.
    Abstract:
    Leukemia inhibitory factor (LIF) is expressed in the hypothalamic-pituitary adrenal (HPA) axis and stimulates pituitary POMC transcription. The role of LIF receptor signaling in HPA axis development was examined. Lifr -/- and Lifr +/+ fetuses were obtained by Cesarean section on E18.5. Despite a 3-fold induction of hypothalamic CRH mRNA, pituitary POMC mRNA and RU486-induced ACTH levels were decreased in Lifr -/- mice. High CRH may be caused by increased central TNFalpha and IL-6 expression. Lifr -/- mice demonstrate elevated pituitary glucocorticoid (GR) and mineralocorticoid (MR) receptor mRNA and protein levels, indicating the importance of LIF signaling for HPA axis development.
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