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  • Title: TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).
    Author: Weeratna RD, Makinen SR, McCluskie MJ, Davis HL.
    Journal: Vaccine; 2005 Nov 01; 23(45):5263-70. PubMed ID: 16081189.
    Abstract:
    TLR ligands that mimic pathogen associated molecular patterns and activate immune cells via Toll-like receptors (TLRs) are being developed for use in humans as therapy against a variety of diseases as well as vaccine adjuvants. These include imidazoquinoline compounds such as Imiquimod and Resiquimod (R-848) that bind to TLR7 and 8, as well as CpG oligodeoxynucleotides (CpG ODN) that bind to TLR9. This study was aimed at comparing CpG ODN and R-848 for their potential use as vaccine adjuvants and to determine whether there are additive or synergistic effects when they are used together. Using HBsAg as a model antigen in mice, we show CpG ODN to be superior to R-848 for augmenting both humoral and cell mediated immune responses.
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