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  • Title: [Comparison of cytological and histological analysis of gastric mucosa biopsy in diagnosing malignant diseases].
    Author: Stromar IK, Jakić-Razumović J, Knezević-Obad A, Knezević J.
    Journal: Lijec Vjesn; 2004; 126(11-12):287-90. PubMed ID: 16082883.
    Abstract:
    The aim of this study was to determine the value of cytological analysis of an imprint of gastric mucosa biopsy compared to the histological evaluation, in diagnosing malignant diseases of gastric mucosa. In this study 70 patients, with changes of gastric mucosa endoscopically suspect of malignancy were included. Biopsy and imprint of gastric mucosa were performed in order to obtain morphological diagnosis. In the investigated group 46 patients (65.7%) were male, 24 patients (34.2%) were female, mean age 60 years (36-83). In 34 patients endoscopy finding suggested malignancy, in 23 endoscopy finding was described as gastric ulcer, in three as duodenal ulcer, in five as polyp, and in five as gastritis. In 42 patients malignancy was proved by pathohistological examination while in imprint smears of gastric mucosa biopsy the diagnosis of malignancy was made in 46 patients. In five patients malignant cells were found on cytological examination of imprint smears, and pathohistological examination did not find malignant tumour. In one patient malignant tumour was found on pathohistological examination, and cytological examination of an imprint smear did not find malignant cells. The results indicate that cytological examination of an imprint smear of gastric mucosa biopsy is satisfactory for proving malignant changes. In case of positive cytological and negative pathohistological analysis, it is recommended to repeat biopsy and imprint cytology in order to obtain morphological diagnosis.
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