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Title: Tyrosine administration does not affect desipramine-induced dopamine levels as measured in vivo in prefrontal cortex. Author: Bongiovanni R, Kirkbride B, Walmire P, Jaskiw GE. Journal: Brain Res; 2005 Aug 30; 1054(2):203-6. PubMed ID: 16083866. Abstract: Using in vivo microdialysis, we examined whether tyrosine administration would potentiate the desipramine (DMI)-induced elevation of medial prefrontal cortex (MPFC) dopamine (DA) levels. DMI (10 or 20 mg/kg IP) increased MPFC DA levels but not DOPA accumulation. Tyrosine (12.5-100 mug/ml) administered by reverse microdialysis did not affect DMI-induced MPFC DA levels. The data support our hypothesis that DA synthesis must be significantly increased in order for administered tyrosine to increase extracellular DA levels.[Abstract] [Full Text] [Related] [New Search]