These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


PUBMED FOR HANDHELDS

Search MEDLINE/PubMed


  • Title: Tyrosine administration does not affect desipramine-induced dopamine levels as measured in vivo in prefrontal cortex.
    Author: Bongiovanni R, Kirkbride B, Walmire P, Jaskiw GE.
    Journal: Brain Res; 2005 Aug 30; 1054(2):203-6. PubMed ID: 16083866.
    Abstract:
    Using in vivo microdialysis, we examined whether tyrosine administration would potentiate the desipramine (DMI)-induced elevation of medial prefrontal cortex (MPFC) dopamine (DA) levels. DMI (10 or 20 mg/kg IP) increased MPFC DA levels but not DOPA accumulation. Tyrosine (12.5-100 mug/ml) administered by reverse microdialysis did not affect DMI-induced MPFC DA levels. The data support our hypothesis that DA synthesis must be significantly increased in order for administered tyrosine to increase extracellular DA levels.
    [Abstract] [Full Text] [Related] [New Search]