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  • Title: Individual changes in lamotrigine plasma concentrations during pregnancy.
    Author: Petrenaite V, Sabers A, Hansen-Schwartz J.
    Journal: Epilepsy Res; 2005 Jul; 65(3):185-8. PubMed ID: 16084694.
    Abstract:
    Eleven pregnant women on lamotrigine (LTG) monotherapy were retrospectively reviewed. A significant decrease in the ratio of plasma LTG concentration-to-dose by 65.1% was observed during the second trimester (TM2) (p=0.0058) and by 65.8% during TM3 (p=0.0045) compared to pre-pregnancy values. Five patients experienced seizure deterioration during pregnancy. The pharmacokinetic changes display marked inter-patient variation, which stresses the importance of evaluating each woman individually by closely monitoring LTG concentrations until term.
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