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  • Title: Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic.
    Author: Baginski M, Sternal K, Czub J, Borowski E.
    Journal: Acta Biochim Pol; 2005; 52(3):655-8. PubMed ID: 16086075.
    Abstract:
    Amphotericin B (AmB) is a well known polyene macrolide antibiotic used to treat systemic fungal infections. Despite its toxicity AmB is still regarded as a life-saving drug. The lack of adequate knowledge of the AmB mechanism of action is a serious obstacle to efficient development of new less toxic derivatives. Complementary to various experimental approaches, computational chemistry methods were used to study AmB mechanism of action. A programme lasting for a decade, that was run by our group covered studies of: i) molecular properties of AmB and its membrane targets, ii) structure and properties of AmB membrane channels, and iii) interaction of AmB with the membrane.
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