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  • Title: Marchiafava-Bignami disease: diffusion-weighted MRI in corpus callosum and cortical lesions.
    Author: Ménégon P, Sibon I, Pachai C, Orgogozo JM, Dousset V.
    Journal: Neurology; 2005 Aug 09; 65(3):475-7. PubMed ID: 16087921.
    Abstract:
    The clinical diagnosis of Marchiafava-Bignami disease (MBD) can be difficult. Acute demyelination of the corpus callosum is characteristic of the disease. The authors report the use of MR diffusion-weighted imaging (DWI) in six cases of acute MBD. They show that apparent diffusion coefficient restriction of the corpus callosum and cortical lesions were associated with a higher mortality rate and more severe cognitive sequelae.
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