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  • Title: Incidence of diarrhea caused by rotavirus infections in rural Zhengding, China: prospective, population-based surveillance.
    Author: Wang XY, Xu ZY, von Seidlein L, Zhang YL, Zhao SJ, Hao ZY, Han OP, Kilgore P, Xing ZC, Han CQ, Ma JC, Chen JC, Clemens J.
    Journal: J Infect Dis; 2005 Sep 01; 192 Suppl 1():S100-5. PubMed ID: 16088791.
    Abstract:
    Rotavirus is the pathogen most commonly associated with severe gastroenteritis in young children in the People's Republic of China, yet there are few population-based data on the incidence of rotavirus infection. The present study investigated the burden of rotavirus diarrhea and rotavirus infections in rural China, according to age. Population-based surveillance was used to study the incidence of rotavirus infection among children <5 years of age in 4 townships of Zhengding County, Hebei Province, China. The total population in the catchment area in 2002 was 75,630 individuals, including 2997 children aged <5 years. Stool samples were obtained and were tested for rotavirus antigen by use of an enzyme-linked immunosorbent assay. During 2002, a total of 2010 cases of diarrhea were detected among children <5 years of age. The incidence of treated cases of diarrhea was 671 cases/1000 children/year for children <5 years of age, and it was highest for children <12 months of age (1467 cases/1000 children/year). The estimated incidence of rotavirus infection was 151 cases/1000 children/year for children <5 years of age. The highest incidence of rotavirus infection was among children aged 1-2 years (340 cases/1000 children/year). Widespread immunization of children against rotavirus before 6 months of age should be considered for the control of rotavirus diarrhea.
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