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  • Title: Translocation of double-strand DNA through a silicon oxide nanopore.
    Author: Storm AJ, Chen JH, Zandbergen HW, Dekker C.
    Journal: Phys Rev E Stat Nonlin Soft Matter Phys; 2005 May; 71(5 Pt 1):051903. PubMed ID: 16089567.
    Abstract:
    We report double-strand DNA translocation experiments using silicon oxide nanopores with a diameter of about 10 nm . By monitoring the conductance of a voltage-biased pore, we detect molecules with a length ranging from 6557 to 48 500 base pairs. We find that the molecules can pass the pore both in a straight linear fashion and in a folded state. Experiments on circular DNA further support this picture. We sort the molecular events according to their folding state and estimate the folding position. As a proof-of-principle experiment, we show that a nanopore can be used to distinguish the lengths of DNA fragments present in a mixture. These experiments pave the way for quantitative analytical techniques with solid-state nanopores.
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