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  • Title: [Propanidid and etomidate identification from the blood by thin-layer chromatography].
    Author: Zawisza P, Przyborowski L.
    Journal: Acta Pol Pharm; 1992; 49(5-6):15-7. PubMed ID: 16092193.
    Abstract:
    Propanidid and etomidate were extracted from blood with diethyl ether at pH ca. 8 (phosphate buffer), then separated and identified by thin-layer chromatography on silica gel, using diethyl ether-acetone (3:1, v/v) for propanidid or dioxane-acetic acid (47:3, v/v) for etomidate as the mobile phase. Both compounds can be revealed on dried chromatograms using sodium carbonate solution up to the amount 1 microg/cm3 of plasma, and it is sufficient sensivity for propanidid adhibited in therapeutic doses, whereas this limits the detection of etomidate for overdosed patients only.
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