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  • Title: Investigation of Fe(III) chloride as a colour reagent for the spectrophotometric determination of bumetanide in the pure form and in preparations.
    Author: Zivanovic L, Agatonovic-Kustrin S, Vasiljevic M, Radulovic D.
    Journal: Acta Pol Pharm; 1992; 49(4):9-12. PubMed ID: 16092427.
    Abstract:
    The formation and stability of the complex between bumetanide (3-butylamino-4-phenoxy-5-sulphamoylbenzoic acid) and Fe(III) ion was studied. It has been found that bumetanide reacts with Fe(III) chloride in the presence of ammonium thiocyanate at the pH 1.83-1.92 to form a violet complex soluble in chlorophorm, with the maximum absorbance at 514.5 nm. At the optimum experimental conditions the conditional stability constant of the complex was found to be log K' = 7.34. The Beer's law was obeyed up to the 160 microg x cm(-3) and the relative standard deviation varied from 0.406% to 0.475% (n = 10). The proposed method was found to be suitable for the accurate and sensitive analysis of bumetanide as a pure compound and from tables and ampoules.
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