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  • Title: Enantioselective Brønsted acid catalyzed transfer hydrogenation: organocatalytic reduction of imines.
    Author: Rueping M, Sugiono E, Azap C, Theissmann T, Bolte M.
    Journal: Org Lett; 2005 Aug 18; 7(17):3781-3. PubMed ID: 16092874.
    Abstract:
    The first enantioselective Brønsted acid catalyzed reduction of imines has been developed. This new organocatalytic transfer hydrogenation of ketimines with Hantzsch dihydropyridine as the hydrogen source offers a mild method to various chiral amines with high enantioselectivity. The stereochemistry of the chiral amines can be rationalized by a stereochemical model derived from an X-ray crystal structure of a chiral BINOL phosphate catalyst. [reaction: see text]
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