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  • Title: The first Negishi cross-coupling reaction of two alkyl centers utilizing a Pd-N-heterocyclic carbene (NHC) catalyst.
    Author: Hadei N, Kantchev EA, O'Brien CJ, Organ MG.
    Journal: Org Lett; 2005 Aug 18; 7(17):3805-7. PubMed ID: 16092880.
    Abstract:
    The development of an NHC-based system capable of cross-coupling sp(3)-sp(3) centers in high yield has been a long-standing challenge. This communication describes the use of a Pd-NHC catalytic system that achieves room-temperature Negishi cross-couplings of unactivated, primary bromides and alkyl organozinc reagents with a variety of functionality. [reaction: see text]
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