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  • Title: A facile Zr-mediated approach to (Z)-enynols and its application to regio- and stereoselective synthesis of fully substituted dihydrofurans.
    Author: Liu Y, Song F, Cong L.
    Journal: J Org Chem; 2005 Aug 19; 70(17):6999-7002. PubMed ID: 16095336.
    Abstract:
    Efficient synthetic approaches to stereodefined (Z)-enynols have been developed through zirconium-mediated cross-coupling reactions of three different components involving alkyne, ketone, and alkynyl bromide in a one-pot procedure. The subsequent electrophilic cyclization of a wide variety of (Z)-enynols affords fully substituted (Z)-5-(1-iodoylidene)-2,5-dihydrofurans with high regio- and stereoselectivity under mild reaction conditions.
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