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  • Title: Atypical neuroleptic malignant syndrome caused by olanzapine.
    Author: Nielsen J, Bruhn AM.
    Journal: Acta Psychiatr Scand; 2005 Sep; 112(3):238-40; discussion 240. PubMed ID: 16095481.
    Abstract:
    OBJECTIVE: Neuroleptic malignant syndrome (NMS) is a rare syndrome with four main symptoms: rigidity, hyperthermia, altered mental status and autonomic instability. We report a patient with an atypical manifestation of NMS. METHOD: A single case was reported. RESULTS: A patient with pneumonia developed delirium and was treated with olanzapine and developed a NMS with fluctuating hyperthermia and autonomic instability during a month. Only slight rigidity was present. Creatine kinase was not elevated. The patient was severely agitated and manic. After discontinuation of olanzapine the patient showed no psychopathology or hyperthermia. CONCLUSION: NMS should be considered when patients treated with antipsychotics develop one or more symptoms of NMS.
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