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  • Title: Fluid retention mediated by renal PPARgamma.
    Author: Staels B.
    Journal: Cell Metab; 2005 Aug; 2(2):77-8. PubMed ID: 16098822.
    Abstract:
    Thiazolidinediones are activators of the nuclear receptor PPARgamma with proven efficacy on glucose homeostasis. However, treatment with these drugs often results in fluid retention and edema. Recent studies establish a role for PPARgamma in renal sodium reabsorption, providing a mechanism for the plasma volume expansion induced by these drugs.
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