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  • Title: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
    Author: Wjst M, van den Boom D.
    Journal: Methods Mol Biol; 2005; 311():125-37. PubMed ID: 16100404.
    Abstract:
    Major strengths of mass spectrometry analysis include the accuracy of the detection principle and the automatic data storage, making it a premier choice for high-throughput single-nucleotide polymorphism genotyping. We explain the assay principle in detail and give step-by-step laboratory instructions. Finally, references point toward further use of mass spectrometry analysis for molecular haplotyping, pooled DNA analysis, re-sequencing, and gene expression studies.
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