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  • Title: A novel HLA allele, DRB1*1609, identified in the Chinese Han population*.
    Author: Miao KR, Pan QQ, Xue M, Zhou XY, Fei XM, Tang YH, Xu R, Zhang JW, Zhao X, Osowski L, Shi WX, Xu AL, Wang CY, KuKuruga D.
    Journal: Tissue Antigens; 2005 Sep; 66(3):248-50. PubMed ID: 16101839.
    Abstract:
    A novel human leucocyte antigen-DRB1*16 (HLA-DRB1*16) allele (DRB1*1609) has been identified by sequencing-based typing (SBT) in Chinese Han population. This new allele has identical nucleotide sequence to DRB1*160101 in exon 2, except for a single-nucleotide substitution from A to T at position 127. This change leads to an amino acid change from tyrosine to phenylalanin at residue 47 (Y47F). SBT was performed for cloned DRB1*16-specific polymerase chain reaction fragment. The serological phenotype of DRB1*1609 is equivalent to DR16 antigen.
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