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  • Title: The effect of hemodynamic changes induced by propofol induction on cerebral oxygenation in young and elderly patients.
    Author: Hung YC, Huang CJ, Kuok CH, Chen CC, Hsu YW.
    Journal: J Clin Anesth; 2005 Aug; 17(5):353-7. PubMed ID: 16102685.
    Abstract:
    STUDY OBJECTIVE: To investigate the difference of regional cerebral oxygen saturation (rSo2) decrease in response to the decrease in mean arterial blood pressure (MAP) in young and elderly patients. DESIGN: Prospective clinical study. SETTING: Medical center hospital. PATIENTS: Twenty-four American Society of Anesthesiologists physical status I and II patients, 12 of whom were young and the other 12 elderly, scheduled for elective surgery requiring general anesthesia. Patients received propofol 2 mg/kg (young patient group) and propofol 1.5 mg/kg (elderly patient group) as an induction drug. MEASUREMENTS: MAP and rSo2 were recorded continuously for 5 minutes after propofol administration. MAIN RESULTS: MAP values at the second to fifth minutes and rSo2 at the second minute after propofol administration were significantly lower than baseline in both groups (P<.05). The rSo2 decrease was minimal, and the slopes of the rSo2 decrease in response to the MAP decrease in the young and elderly groups were 0.093+/-0.012 (P<.001) and 0.112+/-0.016 (P<.001) (mean+/-SEM), respectively. CONCLUSIONS: After propofol induction, there was no difference between young and elderly patients in rSo2 decrease in response to the decrease in MAP.
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