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  • Title: Copper-metallothionein induction in the liver of LEC rats.
    Author: Sakurai H, Kamada H, Fukudome A, Kito M, Takeshima S, Kimura M, Otaki N, Nakajima K, Kawano K, Hagino T.
    Journal: Biochem Biophys Res Commun; 1992 Jun 15; 185(2):548-52. PubMed ID: 1610350.
    Abstract:
    Recently, copper (Cu) was found to be unusually accumulated, suggesting the induction of metallothionein (MT) in the liver of LEC rats (Long-Evans rats with a cinnamon-like coat color), which develop spontaneous jaundice with hereditary hepatitis. Thus, the direct relationship between the unusual Cu accumulation and the induction of Cu-MT was investigated by giving LEC rats Cu-overloaded or Cu-deficient diets. Results based on the determinations of Cu and MT levels in several organs, as well as the gel-filtration profiles of the cytosols of liver homogenates, showed that dietary Cu induced Cu-MT and development of hepatic injury associated with jaundice.
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