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  • Title: Effects of androgen on phosphorylation of chromosomal proteins in mouse submandibular gland.
    Author: Sato N, Yoshida M, Ota M.
    Journal: Biochem Int; 1992 Apr; 26(5):843-52. PubMed ID: 1610385.
    Abstract:
    The effect of androgen on intranuclear distribution of androgen receptor binding sites was studied. The level of the androgen receptor complex in dinucleosomes increased 1 h after androgen treatment and those in the mono- and trinucleosomes increased 3 h after androgen treatment. Investigation by 32P incorporation into the nuclei and active chromatin showed that androgen resulted in an increase in the rate of phosphorylation at 3 h and reduced to the control level at 6 h. These data suggest that association of androgen receptor with the acceptor sites and activities of protein kinase in active chromatin are simultaneously stimulated for activating the transcription by androgen.
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