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  • Title: Function and therapeutic potential of host defence peptides.
    Author: McPhee JB, Hancock RE.
    Journal: J Pept Sci; 2005 Nov; 11(11):677-87. PubMed ID: 16103989.
    Abstract:
    Cationic host defence (antimicrobial) peptides are an important component of the innate immune systems of a wide variety of plants, animals, and bacteria. Although most of these compounds have direct antimicrobial activities under specific conditions, a greater appreciation for the diversity of functions of these molecules is beginning to develop in the field. In addition to their directly antimicrobial activities, they also have a broad spectrum of activity on the host immune system, with both pro-inflammatory and anti-inflammatory effects being invoked. Increasingly sophisticated approaches to understand the role of host defence peptides in modulating innate immunity are already serving to guide the development of novel therapeutics.
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