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  • Title: Synthesis and structure-antimicrobial activity relationships of quaternary ammonium derivatives of perhydropyrrolo-[3,4-c]pyridine.
    Author: Altomare C, Carotti A, Casini G, Cellamare S, Ferappi M, Vitali C.
    Journal: Arzneimittelforschung; 1992 Feb; 42(2):152-5. PubMed ID: 1610427.
    Abstract:
    A large homologous series of quaternary ammonium derivatives of perhydropyrrolo[3,4-c]pyridine 5 was synthesized and tested for in vitro antibacterial activity against different Gram-positive and Gram-negative bacteria. Compounds 5 proved to be always more potent than benzalkonium chloride, taken as reference. Antibacterial activity, expressed as log 1/MIC, was found linearly related to lipophilicity up to C13-C14 homologs, where a break in the linear relationship was observed.
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