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  • Title: Iron-mediated free-radical formation of signaling lipids in a model system.
    Author: Yurkova I, Kisel M, Arnhold J, Shadyro O.
    Journal: Chem Phys Lipids; 2005 Oct; 137(1-2):29-37. PubMed ID: 16105667.
    Abstract:
    It has been shown using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and its combination with thin-layer chromatography (TLC) that the action of the ascorbate/Fe(2+)/H(2)O(2) oxidizing system on cardiolipin and galactocerebroside results in the formation of phosphatidic acid (PA) and ceramide (Cer), respectively. These data, when combined with results obtained on radiolysis of similar substances, allowed the conclusion that the formation of PA and Cer occurs via an OH-induced fragmentation taking place in polar moiety of the starting substrates.
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