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  • Title: Mechanism of action of interferon and ribavirin in treatment of hepatitis C.
    Author: Feld JJ, Hoofnagle JH.
    Journal: Nature; 2005 Aug 18; 436(7053):967-72. PubMed ID: 16107837.
    Abstract:
    Since the identification of the hepatitis C virus, great strides have been made in the development of an antiviral therapy. As a crucial mediator of the innate antiviral immune response, interferon-alpha (IFN-alpha) was a natural choice for treatment. Whereas treatment with IFN-alpha alone achieved only modest success, the addition of the broad-spectrum antiviral agent ribavirin greatly improved responses. However, half of the infected individuals with chronic disease do not achieve sustained clearance of hepatitis C virus. To optimize current therapeutic strategies and to develop new therapies, a better understanding of the mechanism of action of IFN and ribavirin will be essential.
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