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  • Title: [Characteristics of sciatic nerve regeneration in limb blood supply disturbance].
    Author: Honcharuk OO, Tsymbaliuk VI, Kostyns'kyĭ HB.
    Journal: Fiziol Zh (1994); 2005; 51(3):78-82. PubMed ID: 16108229.
    Abstract:
    The submitted work is devoted to a problem of influence of the regional hemodynamic disturbances on nerve regeneration following its full anatomic breakdown and neuroraphy. In a chronic experiment on 30 white rats, an arterial ischemia was reproduced by ligation of the main femoral arteries: common and deep femoral (12 animals), while venous hypertension was reproduced by ligation of the main veins: common, deep femoral and big hypodermic veins (12 animals). In the second stage of the operation a sciatic nerve of the same limb was dissected and its pieces were connected by perineural seam. In the control group 6 animals were subjected to the operation with the subsequent imposition of the perineural seam on the sciatic nerve. In 7, 14, 30, 60, 90 days after operation the tissue block from a zone of neural anastomosis was deleted. Proximal and distal stumps of the operated nerve, reclaiming neuroma and hematomicrocirculating channels of the nerve were investigated by perfusion, histologic and electron-microscopic methods. It is established that the regional ischemia caused by trauma of the main arteries of the limb resulted in inhibition of regenerative processes in the operated nerve, and restoration of arterial blood circulation is essential for stimulation of these processes. Regional venous hypertension is not the critical factor for regeneration of a peripheral nerve after its anatomic breakdown and microsurgical neuroraphy.
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